a team from osaka city university, in collaboration with other international ptners, has demonstrated a reliable and precise microscope-based thermomt that wox'n live, microscopic animals based on quantum tek, specifically, detecting temperature-dependent properties of quantum spins in fluorescent nanodiamonds.
the research is published in sci advances.
the optical microscope is 1-odda most basic tulz for analysis in biology that uses visible lite to allo the naked eye to see microscopic structures. inna modern lab, fluorescence microscope, an enhd version of the optical microscope with various fluorescent biomarkers, is + frequently used. recent advancements in such fluorescence microscopy ‘ve alloed for live imaging of the details offa structure, and through this, obtaining various physiological paramts in these structures, s'as ph, reactive oxygen species, and temperature.
quantum sensing is a tek that exploits the ultimate sensitivity of fragile quantum systems to the surrounding environment. high-contrast mris are exs of quantum spins in fluorescent diamonds and are somd' most advanced quantum systems working atta forefront of real-realm applications. applications of this teknique to thermal biology were introduced 7 yrs ago to quantify temperatures inside cultured cells. however, they had yet to be applied to dynamic biological systems where heat and temperature are + actively involved in biological processes.
the research team decorated the surface of the nanodiamonds with polymer structures and injected them to c. elegans nematode worms, 1-odda most pop model animals in biology. they needed to know the base “healthy” temperature of the worms. once inside, the nanodiamonds moved quickly but'a team’s novel quantum thermometry algorithm successfully tracked them and steadily measured the temperature. a fever was induced within the worms by stimulating their mitochondria witha pharmacological treatment. the team’s quantum thermomt successfully envisaged a temperature increase inna worms.
“twas fascinating to see quantum tek work so well in live animals and i never imagined the temperature of tiny worms ≤ 1 mm in size ‘d deviate from the norm and develop into a fever,” said masazumi fujiwara, a lecturer atta deptment of sci at osaka city university. “our results are an primordial milestone thall guide the future direction of quantum sensing as it shows how it contributes to biology,”
original content at: www.scidaily.com…